Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-6-(trifluoromethyl)nicotinoyl chloride → N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-6-(trifluoromethyl)nicotinoyl chloride | HCID 2775675 | — |
| 반응물 | 4-Chloro-3-iodoaniline | HCID 21874954 | — |
| 생성물 | N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide | HCID 66877122 | — |
반응 단계
Procedure D was performed with 4-chloro-3-iodoaniline (225 mg, 0.889 mmol) and 6-(trifluoromethyl)-2-methylpyridine-3-carbonyl chloride (237 mg, 0/93 mmol, 1.05 eq) at 0° C. for 30 minutes. The crude residue was purified by silica gel chromatography (2-50% ethyl acetate/hexanes) to yield N-(4-chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321761B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-15797ecf73c44352af4473b52998a936 |
| 출처 메모 | uspto-grants-2016_04 |