Chlorosuccinimide → N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine

HRID 633022

반응식

HRID 633022 반응식
[CH2:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:20]N1C(=O)CCC1=O>CN(C=O)C>[CH2:1]([NH:8][C:9]1[S:10][C:11]([Cl:20])=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[N:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 2902584N-benzyl-4-(pyridin-2-yl)thiazol-2-amine

생성물 1

HCID 58614641N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of N-benzyl-4-(pyridin-2-yl)thiazol-2-amine (60 mg, 0.23 mmol) in DMF (2 mL) was cooled to 0° C. and treated with N-chlorosuccinimide (33 mg, 0.25 mmol), and the reaction mixture was allowed to warm to room temperature. The solvent was evaporated, and the product was purified on reverse phase HPLC to produce N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine. MS (Q1) 302.2 (M)+.

후처리

  1. customThe solvent was evaporated
  2. customthe product was purified on reverse phase HPLC

출처 및 근거

ORD 기록
ord-6feebbc8861d4b5da3b074e8e21e8bf8
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321761B2

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