돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 633034생성일: 2026년 10월 25일

2-Bromo-4-ethylpyridine → N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide

https://huagongshe.com/reaction/633034

반응식

참여 물질

역할이름HCID투입량
반응물2-Bromo-4-ethylpyridineHCID 4114248—
반응물N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamideHCID 66896658—
생성물N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamideHCID 58614779—

반응 단계

N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (˜1 mmol) was used in Procedure A with 4-ethyl-2-bromopyridine (1 mmol). Purified by silica gel chromatography (0-60% ethyl acetate/hexanes) to yield N-(4-chloro-3-(4-ethylpyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a tan solid: MS (Q1) 419 (M)+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09321761B2
출처 데이터셋uspto-grants-2016_04
ORD IDord-dfc9f504237e46a2b3906327e634e5ff
출처 메모uspto-grants-2016_04