5-Bromo-3-pyridinecarboxaldehyde → (E)-5-(2-cyclohexylvinyl)nicotinaldehyde

HRID 63306

반응식

HRID 63306 반응식
[CH:1]1(/[CH:7]=[CH:8]/B(O)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[C:13]1[CH:14]=[N:15][CH:16]=[C:17]([CH:20]=1)[CH:18]=[O:19]>>[CH:1]1(/[CH:7]=[CH:8]/[C:13]2[CH:14]=[N:15][CH:16]=[C:17]([CH:20]=2)[CH:18]=[O:19])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 27847345-Bromo-3-pyridinecarboxaldehydeHCID 6031024(2-Cyclohexylvinyl)boronic acid

생성물 1

HCID 86694593(E)-5-(2-cyclohexylvinyl)nicotinaldehyde

실험 절차

Coupling of (E)-(2-cyclohexylvinyl)boronic acid with 5-bromonicotinaldehyde following the method used in Example 3 gave (E)-5-(2-cyclohexylvinyl)nicotinaldehyde as a yellow oil. Yield (0.8 g, 69%); 1H NMR (400 MHz, DMSO-d6) δ 10.08 (s, 1H), 8.32 (s, 1H), 8.75 (s, 1H), 8.28 (s, 1H), 6.51-6.38 (m, 2H), 2.26-2.13 (m, 1H), 1.88-1.58 (m, 5H), 1.42-1.18 (m, 5H).

출처 및 근거

ORD 기록
ord-1cea7e4aa0cd4637bb420b42784e85a3
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447078B2

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