4-(2-Bromoethylsulfonyl)benzonitrile → 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile

반응식

Br[CH2:2][CH2:3][S:4]([C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH3:15][C:16]1[N:17]=[CH:18][NH:19][CH:20]=1>>[CH3:15][C:16]1[N:17]=[CH:18][N:19]([CH2:2][CH2:3][S:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)(=[O:6])=[O:5])[CH:20]=1

참가 물질

반응물 2

HCID 668780144-(2-Bromoethylsulfonyl)benzonitrile

HCID 178418800HCID 178418800, 화합물

생성물 1

HCID 668960954-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile

실험 절차

270 mg of 4-(2-bromoethylsulfonyl)benzonitrile was used in Procedure P with 4-methylimidazole to yield 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile. 320 mg of 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzonitrile was reacted via Procedure T to give 4-(2-(4-methyl-1H-imidazole-1-yl)ethylsulfonyl)benzoic acid.

출처 및 근거

ORD 기록: ord-49bfa8b7ea1b44d88a242b406f5ed4d9
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09321761B2

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