Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 6-[(6-Ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 1,4-Dimercapto-2,3-butanediol | HCID 19001 | — |
| 반응물 | 2-Amino-6-thiocyanato-1,3-benzothiazole | HCID 81600 | — |
| 반응물 | HCID 67524522 | HCID 67524522 | — |
| 촉매 | Monobasic potassium phosphate | HCID 516951 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-[(6-Ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine | HCID 42598895 | 80.3% |
반응 단계
The 6-[(6-ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine was prepared according to the method described in Example 17a, but using 587 mg of 2-amino-1,3-benzothiazol-6-yl thiocyanate (commercial), 20 cm3 of degassed ethanol, 13 mg of potassium dihydrogen phosphate in 0.2 cm3 of water, 1.31 g of DL-dithiothreitol and 562 mg of 3-chloro-6-ethoxy[1,2,4]triazolo[4,3-b]pyridazine. 783 mg of 6-[(6-ethoxy[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulphanyl]-1,3-benzothiazol-2-amine are thus obtained in the form of a whitish powder, the characteristics of which are as follows:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321777B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-542b229f19334344b5bc98c618b6372f |
| 출처 메모 | uspto-grants-2016_04 |