Acetonitrile → 3-(2-(Cyclohexylmethoxy)pyrimidin-4-yl)-3-hydroxypropanenitrile

반응식

[CH:1]1([CH2:7][O:8][C:9]2[N:14]=[C:13]([CH:15]=[O:16])[CH:12]=[CH:11][N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:17][C:18]#[N:19]>>[CH:1]1([CH2:7][O:8][C:9]2[N:14]=[C:13]([CH:15]([OH:16])[CH2:17][C:18]#[N:19])[CH:12]=[CH:11][N:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

반응물 2

HCID 6342Acetonitrile

HCID 866946682-(Cyclohexylmethoxy)pyrimidine-4-carbaldehyde

생성물 1

HCID 866946693-(2-(Cyclohexylmethoxy)pyrimidin-4-yl)-3-hydroxypropanenitrile

실험 절차

CH3CN addition to 2-(cyclohexylmethoxy)pyrimidine-4-carbaldehyde following the method described in Example 6 gives 3-(2-(cyclohexylmethoxy)pyrimidin-4-yl)-3-hydroxypropanenitrile.

출처 및 근거

ORD 기록: ord-a7400561dd554bedba017a8011c12e1f
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09447078B2

반응 노트

불러오는 중…