Sodium methanethiolate → 3-Bromo-2-(2,4-difluorophenoxy)-5-(methylthiomethyl)pyridine

HRID 633557노트

반응식

HRID 633557 반응식
[Br:1][C:2]1[C:3]([O:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])=[N:4][CH:5]=[C:6]([CH2:8]Br)[CH:7]=1.[CH3:19][S-:20].[Na+]>CN(C)C=O>[Br:1][C:2]1[C:3]([O:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])=[N:4][CH:5]=[C:6]([CH2:8][S:20][CH3:19])[CH:7]=1

참가 물질

4

반응물 2

HCID 4378561Sodium methanethiolateHCID 867210763-Bromo-5-(bromomethyl)-2-(2,4-difluorophenoxy)pyridine

생성물 1

HCID 867210773-Bromo-2-(2,4-difluorophenoxy)-5-(methylthiomethyl)pyridine수율 96.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The product from Example 60C (0.75 g, 1.979 mmol) and sodium thiomethoxide (0.139 g, 1.979 mmol) were combined in dimethylformamide (3.96 mL), stirred for 4 hours and partitioned into ethyl acetate and cold water. The organic layer was washed with saturated aqueous sodium chloride, dried (anhydrous Na2SO4), filtered, and concentrated to afford the title compound (0.66 g, 96%).

후처리

  1. custompartitioned into ethyl acetate and cold water
  2. washThe organic layer was washed with saturated aqueous sodium chloride
  3. dry with materialdried (anhydrous Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cf4598693ca34dc095286c6837bfb2c1
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321764B2

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