Dimethylformamide → 1-Bromo-4-((methylsulfonyl)methyl)benzene

HRID 633608노트

반응식

HRID 633608 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.CN(C)C=O.[CH3:15][S:16]([O-:18])=[O:17].[Na+]>O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:16]([CH3:15])(=[O:18])=[O:17])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 685274-Bromobenzyl bromideHCID 2733271Sodium methanesulfinate

생성물 1

HCID 27614151-Bromo-4-((methylsulfonyl)methyl)benzene수율 95.3%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
65 °C

실험 절차

A 250 mL round-bottomed flask was charged with 4-bromobenzyl bromide (5 g, 20 mmol) and N,N-dimethylformamide (10.81 mL). Sodium methanesulfinate (3.06 g, 30 mmol) was added. The reaction mixture was stirred at 65° C. for 1 hour. The reaction mixture was cooled to ambient temperature and diluted with water. The resulting suspension was stirred for 10 minutes and filtered. The solid was rinsed with water and dried under vacuum to provide the title compound (4.75 g, 95% yield).

후처리

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. stirringThe resulting suspension was stirred for 10 minutes
  3. filtrationfiltered
  4. washThe solid was rinsed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-c856bfc92c254b74a6a6d201d98b6e06
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321764B2

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