Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-3-methyl-7-(3-methyl-2-buten-1-yl)-8-chloro-xanthine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Bromomethyl 2-methoxyphenyl ketone | HCID 123440 | — |
| 반응물 | 3-Methyl-7-(3-methyl-2-buten-1-yl)-8-chloro-xanthine | HCID 22029722 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-[2-(2-Methoxy-phenyl)-2-oxo-ethyl]-3-methyl-7-(3-methyl-2-buten-1-yl)-8-chloro-xanthine | HCID 57514535 | — |
반응 단계
1.71 g of 2-bromo-1-(2-methoxy-phenyl)-ethanone are added to a mixture of 2.00 g of 3-methyl-7-(3-methyl-2-buten-1-yl)-8-chloro-xanthine and 1.38 mg of potassium carbonate in 15 ml of N,N-dimethylformamide. The reaction mixture is stirred for eight hours at ambient temperature. After aqueous working up the crude product is purified by chromatography through a silica gel column with cyclohexane/ethyl acetate (8:1 to 8:1) as eluant.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321791B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-e2eaf13ec1dd48e38ec9ac54f1678d2b |
| 출처 메모 | uspto-grants-2016_04 |