Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2,6-Dimethyl-4-(5-pyrimidinyl)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Bromo-2,6-dimethylphenol | HCID 16919 | — |
| 반응물 | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| 생성물 | 2,6-Dimethyl-4-(5-pyrimidinyl)phenol | HCID 68334917 | 20% |
반응 단계
4-Bromo-2,6-dimethylphenol (0.5 g, 2.5 mmol) was dissolved in dimethoxyethane/water (2:1). pyrimidin-5-ylboronic acid (0.37 g, 2.8 mmol), Pd(dppf)Cl2 (0.02 g, 0.13 mmol) and sodium carbonate (0.79 g, 7.5 mmol) were added thereto, followed by reacting in microwave reactor at 120° C. for 15 minutes. After the completion of the reaction, the reaction mixture was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, concentrated under reduced pressure, and purified by column chromatography to obtain 2,6-dimethyl-4-(pyrimidin-5-yl)phenol (0.1 g, 20%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447083B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-34c8f6cb4a13436397cfcea4147ae4c2 |
| 출처 메모 | uspto-grants-2016_09 |