Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 2-Bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 5-Acetyl-4-methylthiazole | HCID 162292 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide | HCID 131735473 | 74.5% |
반응 단계
220 mg (1.56 mmol) of 1-(4-methylthiazol-5-yl)ethanone are dissolved in 10 mL of glacial acetic acid. 769 μl (4.67 mmol) of hydrobromic acid and 88 μl (1.71 mmol) of bromine are added to the medium. The reaction mixture is placed under magnetic stirring at room temperature for 2 hours. Ethyl ether is added to the solution until a precipitate appears. The precipitate corresponding to 2-bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide is filtered off, washed with ethyl ether and dried. The 350 mg of product obtained have the following characteristics:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321790B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-44d8cd39d53b4e44a88f58b454fa5c87 |
| 출처 메모 | uspto-grants-2016_04 |