Ammonium Hydroxide → 1-(2-Aminopyridin-5-yl)ethanone

반응식

Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[OH-].[NH4+:12]>>[NH2:12][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 27796981-(6-Chloropyridin-3-yl)ethan-1-one

생성물 1

HCID 211133961-(2-Aminopyridin-5-yl)ethanone

반응 조건

온도: 130 °C

실험 절차

2 g (11.57 mmol) of 1-(6-chloropyrid-3-yl)ethanone and 70 mL of ammonium hydroxide are placed in a Parr reactor. The solution is heated at 130° C. overnight. The mixture obtained is evaporated to dryness, and the residue is taken up in ethyl acetate and washed with water and with saturated NaCl solution. The organic phase is dried over sodium sulfate and evaporated to dryness to give 1.14 g of 1-(6-aminopyrid-3-yl)ethanone, the characteristics of which are as follows:

후처리

customThe mixture obtained
customis evaporated to dryness
washwashed with water and with saturated NaCl solution
dry with materialThe organic phase is dried over sodium sulfate
customevaporated to dryness

출처 및 근거

ORD 기록: ord-bb41f7a833024d76b26c12616ecec026
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09321790B2

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