1-Boc-4-(aminomethyl)piperidine → 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-piperidin-4-ylmethyl]-amide

HRID 633811

반응식

HRID 633811 반응식
Br[CH2:2][CH:3]1[CH2:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=3)[N:8]=[CH:7][C:6]=2[O:5][CH2:4]1.C(OC([N:26]1[CH2:31][CH2:30][CH:29]([CH2:32][NH2:33])[CH2:28][CH2:27]1)=O)(C)(C)C.[O:34]=[C:35]1[NH:40][C:39]2[CH:41]=[C:42]([C:45](O)=[O:46])[CH:43]=[CH:44][C:38]=2[S:37][CH2:36]1>>[CH3:18][O:17][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]1[O:5][CH2:4][CH:3]([CH2:2][N:26]3[CH2:27][CH2:28][CH:29]([CH2:32][NH:33][C:45]([C:42]4[CH:43]=[CH:44][C:38]5[S:37][CH2:36][C:35](=[O:34])[NH:40][C:39]=5[CH:41]=4)=[O:46])[CH2:30][CH2:31]3)[CH2:16][C:15]2=1

참가 물질

4

반응물 3

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 867307013-bromomethyl-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthrene

생성물 1

HCID 714754833-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-piperidin-4-ylmethyl]-amide

실험 절차

The titled compound is prepared as an off-white lyophilized powder following Scheme 1 and in analogy to Example 1 using 3-bromomethyl-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthrene, 4-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

출처 및 근거

ORD 기록
ord-41dd737fe7cd445c89456a7f38af6aef
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321788B2

연결된 노트

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