Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-piperidin-4-yl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid | HCID 760993 | — |
| 반응물 | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| 반응물 | 3-bromomethyl-5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthrene | HCID 86730710 | — |
| 생성물 | 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-piperidin-4-yl]-amide | HCID 71475525 | — |
반응 단계
The titled compound is prepared as a white lyophilized powder following Scheme 1 and in analogy to Example 1 using 3-bromomethyl-5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthrene, 4-amino-piperidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321788B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-cbfae806eea648a491e560457c6dc52f |
| 출처 메모 | uspto-grants-2016_04 |