3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → 1-(6-methoxy-3,4-dihydro-2H-1-thia-9-aza-phenanthren-3-ylmethyl)-4-[(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carbonyl)-amino]-pyrrolidine-2-carboxylic acid methyl ester

반응식

Br[CH2:2][CH:3]1[CH2:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=3)[N:8]=[CH:7][C:6]=2[S:5][CH2:4]1.[CH3:19][O:20][C:21]([CH:23]1[CH2:27][CH:26]([NH2:28])[CH2:25][N:24]1C(OC(C)(C)C)=O)=[O:22].[O:36]=[C:37]1[NH:42][C:41]2[CH:43]=[C:44]([C:47](O)=[O:48])[CH:45]=[CH:46][C:40]=2[S:39][CH2:38]1>>[CH3:19][O:20][C:21]([CH:23]1[CH2:27][CH:26]([NH:28][C:47]([C:44]2[CH:45]=[CH:46][C:40]3[S:39][CH2:38][C:37](=[O:36])[NH:42][C:41]=3[CH:43]=2)=[O:48])[CH2:25][N:24]1[CH2:2][CH:3]1[CH2:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=3)[N:8]=[CH:7][C:6]=2[S:5][CH2:4]1)=[O:22]