4-Fluoro-2-(3-furanyl)-6-methylphenol → 4-Fluoro-2-methyl-6-(tetrahydro-3-furanyl)phenol

HRID 63389노트

반응식

HRID 63389 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([OH:9])=[C:4]([C:10]2[CH:14]=[CH:13][O:12][CH:11]=2)[CH:3]=1>CO.[C].[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:14][CH2:13][O:12][CH2:11]2)[C:5]([OH:9])=[C:6]([CH3:8])[CH:7]=1

참가 물질

4

반응물 1

HCID 900021994-Fluoro-2-(3-furanyl)-6-methylphenol2회

생성물 1

HCID 900024614-Fluoro-2-methyl-6-(tetrahydro-3-furanyl)phenol수율 76.5%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

4-fluoro-2-(furan-3-yl)-6-methylphenol (Compound 6-11) (471 mg, 2.45 mmol) were dissolved in methanol. Palladium carbon (64.3 mg, 5 wt %) was added thereto, followed by stirring under hydrogen balloon for 24 hours. After the completion of the reaction, the reaction mixture was filtered through Celite. The filtrate was concentrated under reduced pressure. The concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1) to obtain 4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenol (368 mg, 76%) as a white solid.

후처리

  1. customAfter the completion of the reaction
  2. filtrationthe reaction mixture was filtered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customThe concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1)

출처 및 근거

ORD 기록
ord-e773a31ef3d840e982973265efadae63
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447083B2

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