Pyridine → HCID 13187521, 화합물

HRID 634711노트

반응식

HRID 634711 반응식
[CH:1]1([O:6][CH2:7][CH2:8][OH:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:10]1(C)[CH:15]=[CH:14][CH:13]=[C:12]([S:16](Cl)(=[O:18])=[O:17])[CH:11]=1.N1C=CC=C[CH:22]=1>>[C:15]1([CH3:22])[CH:10]=[CH:11][C:12]([S:16]([O:9][CH2:8][CH2:7][O:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:17])=[O:18])=[CH:13][CH:14]=1

참가 물질

4

반응물 3

HCID 1049Pyridine2회HCID 27345953-Methylbenzenesulphonyl chlorideHCID 131875202-(Cyclopentyloxy)ethan-1-ol

생성물 1

HCID 13187521HCID 13187521, 화합물수율 73%

실험 절차

2-Cyclopentyloxyethanol (4.3 g, 33.1 mmol) in pyridine (18 ml) was added dropwise to a solution of 3-toluenesulphonyl chloride (6.8 g, 35.7 mmol) in pyridine (27 ml) at 5° C. The mixture was allowed to warm to ambient temperature, and stirred overnight. The mixture was poured onto ice containing concentrated hydrochloric acid (46 ml) and the product was extracted with ether. The organic phase was washed with 2M hydrochloric acid, dried (MgSO4) and the solvent removed by evaporation to give 2-cyclopentyloxyethyl 4-toluenesulphonate (6.9 g, 73%) which was used without further purification.

후처리

  1. additionThe mixture was poured onto ice containing concentrated hydrochloric acid (46 ml)
  2. extractionthe product was extracted with ether
  3. washThe organic phase was washed with 2M hydrochloric acid
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed by evaporation

출처 및 근거

ORD 기록
ord-cd77fb3878904afc8634985bf4a3df0d
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184225B2

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