4-(4-Benzylaminosulfonylmethylbenzyl)-nitrobenzene → 4-(4-Benzylaminosulfonylmethylbenzyl)-phenylamine

HRID 634817노트

반응식

HRID 634817 반응식
[CH2:1]([NH:8][S:9]([CH2:12][C:13]1[CH:28]=[CH:27][C:16]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=2)=[CH:15][CH:14]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pd]>[CH2:1]([NH:8][S:9]([CH2:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([NH2:24])=[CH:22][CH:23]=2)=[CH:27][CH:28]=1)(=[O:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 218767514-(4-Benzylaminosulfonylmethylbenzyl)-nitrobenzene

생성물 1

HCID 218769594-(4-Benzylaminosulfonylmethylbenzyl)-phenylamine수율 95.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 4-(4-benzylaminosulfonylmethylbenzyl)-nitrobenzene (44 mg) was dissolved in ethyl acetate and hydrogenated at 40 psi with 10% palladium on carbon catalyst for 2 hours. The mixture was filtered, and the solvent was evaported to give 4-(4-benzylaminosulfonylmethylbenzyl)-phenylamine (39 mg) as an off-white solid.

후처리

  1. filtrationThe mixture was filtered

출처 및 근거

ORD 기록
ord-10a620ee54fe432099073948578b0a51
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184242B2

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