Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3,5,6-Tetrafluorophenol → N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenyloxy)-pentanoic acid, tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3,5,6-Tetrafluorophenol | HCID 69858 | — |
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 반응물 | N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-5-bromo-4-oxo-pentanoic acid, tert-butyl ester | HCID 86756364 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[(1-methyl-3-isobutyl-indole-2-cabonyl)leucinyl]-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenyloxy)-pentanoic acid, tert-butyl ester | HCID 86756363 | 72.4% |
반응 단계
The titled product (47.6 mg, 72%, white solid) was prepared as described in Example 82 using the product of Example 88 (57.6 mg, 0.097 mmol), potassium fluoride (18.5 mg, 0.24 mmol), and 2,3,5,6-tetrafluorophenol (21.1 mg, 0.097 mmol) in DMF (2.0 ml). TLC (hexane/EtOAc, 50/50): Rf=0.55.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06184244B2 |
| 출처 데이터셋 | uspto-grants-2001_02 |
| ORD ID | ord-a522d2b1178044bea514733c1e72cef4 |
| 출처 메모 | uspto-grants-2001_02 |