Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → (E)-Ethyl 3-(1-((tert-butoxycarbonyl)amino)cyclopropyl)acrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| 반응물 | (1-Formylcyclopropyl)carbamic acid tert-butyl ester | HCID 10352385 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (E)-Ethyl 3-(1-((tert-butoxycarbonyl)amino)cyclopropyl)acrylate | HCID 11777121 | 61% |
반응 단계
1-Tert-butoxycarbonylaminocyclopropane carbaldehyde (10.99 g, 59.3 mmol) and (carbethoxymethylene) triphenylphosphorane (27.6 g, 75.2 mmol) were dissolved in dichloromethane (300 ml) and heated under reflux for 4 hours. After evaporating the solvent, the resulting residue was applied to a silica gel chromatography column and eluted with an eluant of n-hexane:ethyl acetate=9:1, to thereby obtain 9.23 g (61%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06184388B2 |
| 출처 데이터셋 | uspto-grants-2001_02 |
| ORD ID | ord-5dd4c89717ee406cb2fa55f2bc65756a |
| 출처 메모 | uspto-grants-2001_02 |