Ethanol → 1-(2-Chloro-5-pyridylmethyl)-5-ethyl-2-nitroiminohexahydro-1,3,5-triazine

HRID 635172노트

반응식

HRID 635172 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]([NH:12][N+:13]([O-:15])=[O:14])=[NH:11])=[CH:4][N:3]=1.[CH2:16]([NH2:18])C.[CH2:19]=O.[CH2:21](O)[CH3:22]>O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:16][N:18]([CH2:21][CH3:22])[CH2:19][NH:11][C:10]2=[N:12][N+:13]([O-:15])=[O:14])=[CH:4][N:3]=1

참가 물질

6

반응물 4

HCID 702EthanolHCID 712FormaldehydeHCID 6341EthylamineHCID 178512104HCID 178512104, 화합물

생성물 1

HCID 1364010701-(2-Chloro-5-pyridylmethyl)-5-ethyl-2-nitroiminohexahydro-1,3,5-triazine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirring mixture of 1 g of 1-(2-chloro-5-pyridylmethyl)-3-nitroguanidine, 0.28 g of 70% ethylamine in water and 20 ml of ethanol, 0.71 g of 37% formalin solution was added dropwise with heating. The reaction mixture was heated under reflux for two hours. After being allowed to cool to room temperature, the crystals formed, which were filtrated off and recrystallized from methanol to obtain 1.15 g of the title compound. This compound is No. 2 in Table 1. m.p.: 124-125° C.

후처리

  1. additionwas added dropwise
  2. temperaturewith heating
  3. temperatureThe reaction mixture was heated
  4. temperatureunder reflux for two hours
  5. customthe crystals formed
  6. filtrationwhich were filtrated off
  7. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-9b8890ccb9ef4a74bfcb4ffe1e265c48
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187773B1

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