1-Phenyl-3-pentene → 2-(2-n-Propoxyphenyl)-8-(5-Phenyl-3-Penten-3-yl)Quinazolin-4(3H)-One

반응식

[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[NH:20][C:19](=[O:21])[C:18]2[C:13](=[C:14](I)[CH:15]=[CH:16][CH:17]=2)[N:12]=1)[CH2:2][CH3:3].[C:23]1([CH2:29][CH2:30][CH:31]=[CH:32][CH3:33])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[NH:20][C:19](=[O:21])[C:18]2[C:13](=[C:14]([C:31](=[CH:30][CH2:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:32][CH3:33])[CH:15]=[CH:16][CH:17]=2)[N:12]=1)[CH2:2][CH3:3]

참가 물질

반응물 2

HCID 5194211-Phenyl-3-pentene

HCID 1355493722-(2-n-Propoxyphenyl)-8-Iodoquinazolin-4(3H)-One

생성물 1

HCID 1359690052-(2-n-Propoxyphenyl)-8-(5-Phenyl-3-Penten-3-yl)Quinazolin-4(3H)-One수율 64.6%

실험 절차

The title compounds are prepared analogously to the method of Example 1, starting with the compound from Example III and 5-phenyl-2-pentene.

출처 및 근거

ORD 기록: ord-1d676572627b4915bd68ac95d2ba3770
출처 데이터셋: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06187779B1

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