Trimethyl phosphite → 4-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester

반응식

[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11]Br)=[CH:7][CH:6]=1)=[O:4].[P:13]([O:18]C)([O:16][CH3:17])[O:14][CH3:15]>>[CH3:1][O:2][C:3](=[O:4])[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][P:13]([O:16][CH3:17])([O:14][CH3:15])=[O:18])=[CH:7][CH:6]=1

참가 물질

반응물 2

HCID 8472Trimethyl phosphite

HCID 256687Methyl 4-(bromomethyl)benzoate2회

생성물 1

HCID 108011704-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester

실험 절차

Methyl 4-(bromomethyl) benzoate (compound 47) (11.2 g, 49 mmol) was dissolved in 25 mL trimethyl phosphite and refluxed under N2 for 5 hrs. Excess trimethyl phosphite was removed by co-distillation with toluene to give crude 4-(Dimethoxy-phosphorylmethyl)-benzoic acid methyl ester (compound 48).

후처리

temperaturerefluxed under N2 for 5 hrs
customExcess trimethyl phosphite was removed by co-distillation with toluene

출처 및 근거

ORD 기록: ord-3d483c3b74624bc3b5db8015348cd15f
출처 데이터셋: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06187792B1

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