1-(4-Fluorophenyl)piperazine → 4-(4-Fluorophenyl)-1-(4-oxo-4-(2-oxocyclohexyl)butyryl)piperazine
반응식
[O:1]=[C:2]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=[O:14])[CH2:3][CH2:4][C:5]([OH:7])=O.[F:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[CH:18][CH:17]=1.N1NC(CCC(O)=O)=C2C=1CCCC2.ClC1C=CC(C2CCNCC2)=CC=1>>[F:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[CH2:27][CH2:26][N:25]([C:5](=[O:7])[CH2:4][CH2:3][C:2](=[O:1])[CH:8]3[CH2:13][CH2:12][CH2:11][CH2:10][C:9]3=[O:14])[CH2:24][CH2:23]2)=[CH:20][CH:21]=1참가 물질
5
실험 절차
4-Oxo-4-(2-oxocyclohexyl)-n-butyric acid (4.0 g) and 1-(4-fluorophenyl)piperazine (3.6 g) were used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Example 102 and 4-(4-chlorophenyl)piperidine, 7.4 g of 4-(4-fluorophenyl)-1-(4-oxo-4-(2-oxocyclohexyl)butyryl)piperazine was obtained.