Ethanol → 3-[1-(3,4-Dichlorophenyl)cyclopentyl]-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

HRID 635352노트

반응식

HRID 635352 반응식
[Br:1][CH2:2][C:3]([C:5]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)=O.[NH:18]1[CH2:22][CH2:21][NH:20][C:19]1=[S:23].C(O)C>C(O)(=O)C>[BrH:1].[Cl:17][C:12]1[CH:11]=[C:10]([C:5]2([C:3]3[N:20]4[CH2:21][CH2:22][N:18]=[C:19]4[S:23][CH:2]=3)[CH2:9][CH2:8][CH2:7][CH2:6]2)[CH:15]=[CH:14][C:13]=1[Cl:16]

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 212585122-Bromo-1-[1-(3,4-dichlorophenyl)cyclopentyl]ethanone

생성물 1

HCID 212584093-[1-(3,4-Dichlorophenyl)cyclopentyl]-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 2-bromo-1-[1-(3,4-dichlorophenyl)cyclopentyl]ethanone (0.5 g), imidazolidine-2-thione (0.16 g), ethanol (3 ml) and acetic acid (2 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The solvents were removed in vacuo and the residue crystallised from a 1:1 mixture of ethyl acetate and ethanol. The resulting product was collected by filtration, washed with ethanol (3 ml) and dried in vacuo at 60° C. to give 3-[1-(3,4-dichlorophenyl)cyclopentyl]-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide as white microneedles (0.27 g), m.p. 230-232° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customThe solvents were removed in vacuo
  4. customthe residue crystallised from a 1:1 mixture of ethyl acetate and ethanol
  5. filtrationThe resulting product was collected by filtration
  6. washwashed with ethanol (3 ml)
  7. customdried in vacuo at 60° C.

출처 및 근거

ORD 기록
ord-c910e2123d8c44a8b4fa76c3ac018f61
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187802B1

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