Bromine → 1-Bromo-3-(3,4-dichlorophenyl)-3-methylbutan-2-one

HRID 635366노트

반응식

HRID 635366 반응식
[Br:1]Br.[Cl:3][C:4]1[CH:5]=[C:6]([C:11]([CH3:16])([CH3:15])[C:12](=[O:14])[CH3:13])[CH:7]=[CH:8][C:9]=1[Cl:10]>CCOCC>[Br:1][CH2:13][C:12](=[O:14])[C:11]([C:6]1[CH:7]=[CH:8][C:9]([Cl:10])=[C:4]([Cl:3])[CH:5]=1)([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 24408Bromine2회HCID 212584633-(3,4-Dichlorophenyl)-3-methylbutan-2-one

생성물 1

HCID 212583981-Bromo-3-(3,4-dichlorophenyl)-3-methylbutan-2-one

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of bromine (1.84 ml) in ether (25 ml) was added dropwise over 1 hour at ambient temperature to a stirred solution of 3-(3,4-dichlorophenyl)-3-methylbutan-2-one (8.24 g) in ether (250 ml). After the addition was complete and the bromine colour had dissipated, the mixture was stirred at ambient temperature for a further 30 minutes then it was washed with water (100 ml), saturated aqueous sodium hydrogen carbonate solution (2×100 ml) and water (100 ml), dried (MgSO4), and the solvent removed in vacuo to give 1-bromo-3-(3,4-dichlorophenyl)-3 methylbutan-2-one as an oil (9.57 g) which was used without purification.

후처리

  1. additionAfter the addition
  2. washit was washed with water (100 ml), saturated aqueous sodium hydrogen carbonate solution (2×100 ml) and water (100 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-f4432f27840448dfbfc35022ab7c5e91
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187802B1

반응 노트

불러오는 중…