Ethanol → N-(4-cyanophenyl)-4-amino-3-nitropyridine

HRID 6355

반응식

HRID 6355 반응식
[C:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)#[N:2].Cl[C:11]1C=C[N:14]=[CH:13][C:12]=1[N+:17]([O-:19])=[O:18].[CH2:20](O)[CH3:21]>>[C:1]([C:3]1[CH:9]=[CH:8][C:6]([N:7]2[CH:21]=[CH:20][C:13]([NH2:14])=[C:12]([N+:17]([O-:19])=[O:18])[CH2:11]2)=[CH:5][CH:4]=1)#[N:2]

참가 물질

4

반응물 3

HCID 702EthanolHCID 133964-AminobenzonitrileHCID 27357814-Chloro-3-nitropyridine

생성물 1

HCID 19791284N-(4-cyanophenyl)-4-amino-3-nitropyridine

실험 절차

According to the method of J. C. S. Perkin Trans. I, 1979, 135, p-cyanoaniline (6.894 g, 58.4 mmol) was added to a solution of 4-chloro-3-nitropyridine (9.26 g, 58.4 mmol) in ethanol (200 ml) and the mixture was stirred at room temperature for 18 hours. The resulting yellow suspension was poured into 500 ml of ice-cold dilute ammonia and filtered. The solid was treated with 150 ml of boiling ethanol, cooled in ice, and filtered to give N-(4-cyanophenyl)-4-amino-3-nitropyridine, 12.15 g, as a bright yellow powder, m.p. 210°-211° C.

후처리

  1. filtrationfiltered
  2. additionThe solid was treated with 150 ml of boiling ethanol
  3. temperaturecooled in ice
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-2bc83680343e4dc3bafc2ceb0ba1db4f
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05248681

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