4-Nitrobenzoyl chloride → 5'-O-p-Nitrobenzoyl-2-N-Isobutyryldeoxyguanosine

HRID 635500노트

반응식

HRID 635500 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:13]([NH:18][C:19]1[NH:20][C:21](=[O:36])[C:22]2[N:23]=[CH:24][N:25]([C:34]=2[N:35]=1)[C@@H:26]1[O:33][C@H:30]([CH2:31][OH:32])[C@@H:28]([OH:29])[CH2:27]1)(=[O:17])[CH:14]([CH3:16])[CH3:15]>N1C=CC=CC=1>[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([O:32][CH2:31][C@H:30]2[O:33][C@@H:26]([N:25]3[C:34]4[N:35]=[C:19]([NH:18][C:13](=[O:17])[CH:14]([CH3:15])[CH3:16])[NH:20][C:21](=[O:36])[C:22]=4[N:23]=[CH:24]3)[CH2:27][C@@H:28]2[OH:29])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 85024-Nitrobenzoyl chlorideHCID 135407017Guanosine, 2'-deoxy-N-(2-methyl-1-oxopropyl)-

생성물 1

HCID 1371829645'-O-p-Nitrobenzoyl-2-N-Isobutyryldeoxyguanosine

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

The synthesis of this product is carried out by reacting 1.1 eq of p-nitrobenzoyl chloride with 2-N-isobutyryldeoxyguanosine for 16 hours in pyridine. After extraction with a dichloromethane/sodium bicarbonate mixture and evaporation to dryness, the product is taken up in chloroform. This product was not used because it was too insoluble.

후처리

  1. customThe synthesis of this product
  2. customfor 16 hours
  3. extractionAfter extraction
  4. customwith a dichloromethane/sodium bicarbonate mixture and evaporation to dryness

출처 및 근거

ORD 기록
ord-9a69e84c0a0941aaba3f666c4f9434bd
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187914B1

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