Pyrazinamide → 2-Pyrazinecarboxylic acid

HRID 635533

반응식

HRID 635533 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7](N)=[O:8].CN(C)C=[O:13]>S(Cl)(Cl)=O>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([OH:8])=[O:13]

참가 물질

4

반응물 2

HCID 1046PyrazinamideHCID 6228Dimethylformamide

생성물 1

HCID 10472-Pyrazinecarboxylic acid수율 111.6%

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

실험 절차

Thionyl chloride (10 mL) is added to a 25 mL round bottom flask in an ice bath. To the flask is added 800 mg (6.5 mmole) of 2-Pyrazinecarboxylic acid 74, and the mixture stirred for 5 minutes. Dimethyl formamide (1.02 g mg, 14 mmole) is added in a single portion, and the orange/red solution stirred for 90 minutes. The solvents are removed under reduced pressure to give 80 (0.900 g).

후처리

  1. stirringthe orange/red solution stirred for 90 minutes
  2. customThe solvents are removed under reduced pressure

출처 및 근거

ORD 기록
ord-ebc97d578ea74eb19d74918e05610308
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187928B1

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