Toluene → (E)-tert-Butyl hept-2-enoate

반응식

[C:1]([OH:9])(=[O:8])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH3:7].[C:10]1([CH3:16])[CH:15]=CC=C[CH:11]=1>>[C:1]([O:9][C:10]([CH3:16])([CH3:15])[CH3:11])(=[O:8])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

반응물 2

HCID 1140Toluene

HCID 52827092-Heptenoic acid

생성물 1

HCID 15636290(E)-tert-Butyl hept-2-enoate

실험 절차

74.79 ml (312 mmol) of 1,2-(di-tert-butyl)trimethylamine were added to a stirred mixture of 5 g (39 mmol) of (E)-2-heptenoic acid in 100 ml of toluene at 80° C. The mixture was stirred under reflux for 30 minutes and then cooled to room temperature. The mixture was washed in sequence with water and saturated sodium bicarbonate solution, then dried over anhydrous magnesium sulphate and filtered. The solvent was removed by evaporation. There were obtained 7.5 g of tert-butyl (E)-2-heptenoate as a yellow oil; MS: m/e 185.0 [M+H].

후처리

temperatureunder reflux for 30 minutes
washThe mixture was washed in sequence with water and saturated sodium bicarbonate solution
dry with materialdried over anhydrous magnesium sulphate
filtrationfiltered
customThe solvent was removed by evaporation

출처 및 근거

ORD 기록: ord-9780b1716e3747bd9ff011df2d496175
출처 데이터셋: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06187905B1

반응 노트

불러오는 중…