Benzo(d)thiazol-2-amine → HCID 15086004, 화합물

HRID 635858노트

반응식

HRID 635858 반응식
C([O:3][C:4]([C:6]1[N:13]2[C:9]([S:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=32)=[N:8][CH:7]=1)=O)C.NC1SC2C=CC=CC=2N=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[N:8]1[CH:7]=[C:6]([CH2:4][OH:3])[N:13]2[C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[S:10][C:9]=12

참가 물질

5

반응물 3

HCID 8706Benzo(d)thiazol-2-amineHCID 10890197HCID 10890197, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 15086004HCID 15086004, 화합물수율 74%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of imidazo[2,1-b]benzothiazole-3-carboxylic acid ethyl ester (Formula J-1), (synthesized from 2-aminobenzothiazole by a modification of the procedures described by Fajeli et al., Heterocycles, 1986, 24, 379) (4.5 g) in THF (75 mL) was treated with LiAlH4 (0.91 g) and reacted for 5.25 hours. The suspension was quenched by serial additions of water and 15% sodium hydroxide. The suspension was diluted with THF and filtered. The filtrate was evaporated, the residue was triturated with hexane to yield imidazo[2,1-b]benzothiazole-3-methanol (Formula J-2) (2.77 g, 74%). Crude imidazo[2,1-b]benzothiazole-3-methanol (Formula J-2) was used without further purification.

후처리

  1. customreacted for 5.25 hours
  2. customThe suspension was quenched by serial additions of water and 15% sodium hydroxide
  3. additionThe suspension was diluted with THF
  4. filtrationfiltered
  5. customThe filtrate was evaporated
  6. customthe residue was triturated with hexane

출처 및 근거

ORD 기록
ord-8312ea30ccbc4a19a959fcdae9488630
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06191124B1

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