Sodium Methoxide → (+)-9-(3-Bromo-4-fluorophenyl)-2,3,5,9-tetrahydro-4h-pyrano[3,4-b]thieno[2,3-e]pyridin-8(7h)-one 1,1-dioxide

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Methoxide	HCID 10942334	—
반응물	(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydro-4H-pyrano[3,4-b]thieno[2,3-e]pyridine-4-carboxylate 1,1-dioxide	HCID 69303668	—
촉매	Methanol	HCID 887	—
용매	Dichloromethane methanol	HCID 21226129	—
생성물	(+)-9-(3-Bromo-4-fluorophenyl)-2,3,5,9-tetrahydro-4h-pyrano[3,4-b]thieno[2,3-e]pyridin-8(7h)-one 1,1-dioxide	HCID 9887983	62.1%

반응 단계

A solution of Example 12A (0.98 g, 1.4 mmol) in methanol/methylene chloride (40 mL/10 mL) was degassed with nitrogen, treated with of 25% sodium methoxide in methanol (30 drops), stirred for 16 hours, filtered through a 45 mm syringe filter and concentrated to a volume of 5 mL of methanol. The solid which had precipitated was collected by filtration, washed with methanol and dried under vacuum for 16 hours to provide the title compound (0.36 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06191140B1
출처 데이터셋	uspto-grants-2001_02
ORD ID	ord-1732fe06a1d141a9867e722956426a68
출처 메모	uspto-grants-2001_02