p-Bromoacetophenone → 4'-Piperidinoacetophenone

HRID 635999노트

반응식

HRID 635999 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>>[N:11]1([C:2]2[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

3

반응물 2

HCID 7466p-BromoacetophenoneHCID 8082Piperidine

생성물 1

HCID 825614'-Piperidinoacetophenone

실험 절차

without solvents (e.g. B. G. Kresze and H. Goetz, Chem. Berichte 90, 2161, 2174 (1957)), reaction of p-bromoacetophenone with piperidine under reflux with 19% yields of 1-(4-piperidinophenyl)ethanone; or

후처리

  1. temperatureunder reflux with 19%

출처 및 근거

ORD 기록
ord-2505275a5aa945bea183576383635ace
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06191182B1

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