Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Chloroperbenzoic acid → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | 5-Bromo-6-chloro-2-(methylsulfanyl)pyrimidin-4-amine | HCID 12369427 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine | HCID 86677016 | 98.9% |
반응 단계
To a stirring solution of 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine (intermediate 1) (52.2 mmol) in 450 ml of DCM, a solution of 12.9 g (57.4 mmol) of m-chloroperbenzoic acid (77%) (Sigma-Aldrich) in 100 ml of DCM was slowly added. The reaction mixture was stirred at room temperature for 1 hour. The formed white precipitate was filtered, washed several times with DCM and dried. 13.96 g of 5-bromo-6-chloro-2-(methylsulfinyl)pyrimidine-4-amine were obtained (98.9%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447095B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-54da99abe4104ef5a9c928da98e967bc |
| 출처 메모 | uspto-grants-2016_09 |