(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 178501428, 화합물

HRID 636155

반응식

HRID 636155 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.Cl.[CH3:20][O:21][C:22](=[O:31])[C@H:23]([CH2:25][C:26]1[N:30]=[CH:29][NH:28][CH:27]=1)[NH2:24]>CO.C(Cl)Cl>[CH3:20][O:21][C:22](=[O:31])[C@H:23]([CH2:25][C:26]1[N:30]=[CH:29][NH:28][CH:27]=1)[NH:24][C:15](=[O:17])[C@H:13]([CH3:14])[NH:12][C:10](=[O:11])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1

참가 물질

4

반응물 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 178419105HCID 178419105, 화합물

생성물 1

HCID 178501428HCID 178501428, 화합물

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2) and L-histidine methyl ester dihydrochloride (Sigma), the title compound was prepared as a solid (mp=195-197° C.). The reaction was monitored by tlc (Rf=0.29 in 10% CH3OH/CH2Cl2).

출처 및 근거

ORD 기록
ord-fde0312b335f4ca8ae2fe279155cb55f
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06191166B1

연결된 노트

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