Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tyrosine Methyl Ester → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tyrosine Methyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tyrosine Methyl Ester | HCID 70652 | — |
| 반응물 | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| 생성물 | N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tyrosine Methyl Ester | HCID 10180420 | — |
반응 단계
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-tyrosine methyl ester (Bachem), the title compound was prepared as a solid (mp=85-88° C.). The reaction was monitored by tlc (Rf=0.27 in 50% EtOAc/hexanes) and the product was purified by silica gel column chromatography.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06191166B1 |
| 출처 데이터셋 | uspto-grants-2001_02 |
| ORD ID | ord-333af5f0f1b840e18c6abaf4d8e71dba |
| 출처 메모 | uspto-grants-2001_02 |