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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 636164생성일: 2026년 10월 26일

Hydrochloric Acid → H-Ala(3-pyridyl)-OMe.2HCl

https://huagongshe.com/reaction/636164

반응식

참여 물질

역할이름HCID투입량
반응물Hydrochloric AcidHCID 313—
반응물Diethyl acetamido[(pyridin-3-yl)methyl]propanedioateHCID 13817914—
생성물H-Ala(3-pyridyl)-OMe.2HClHCID 46862166100%

반응 단계

Diethyl 2-(3-pyridylmethyl)-2-acetamidomalonate was dissolved in 6N HCl (30 mL) and heated to reflux for 19 hours whereupon it was cooled to room temperature and the HCl solution was removed by evaporation in vacuo. The intermediate amino acid dihydrochloride salt was taken up into MeOH (30 mL) saturated with HCl gas and stirred for 3.5 hours. The MeOH/HCl was removed by evaporation in vacuo to give 3-(3-pyridyl)alanine methyl ester dihydrochloride (2.235 g, 100%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06191166B1
출처 데이터셋uspto-grants-2001_02
ORD IDord-3b4eb682c8a3415d896cf748e834412d
출처 메모uspto-grants-2001_02