Hydrazine → HCID 178509275, 화합물

HRID 636418노트

반응식

HRID 636418 반응식
[NH2:1]N.[C:3]1([S:9]([C:12](=[CH:15][N:16](C)C)[C:13]#[N:14])(=[O:11])=[O:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CCO>[C:3]1([S:9]([C:12]2[C:15]([NH2:16])=[N:1][NH:14][CH:13]=2)(=[O:10])=[O:11])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 42101212-(Benzenesulfonyl)-3-(dimethylamino)prop-2-enenitrile

생성물 1

HCID 178509275HCID 178509275, 화합물수율 30%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.05 ml (40.9 mmol) of NH2NH2 were added to a solution of 9.08 g (38.3 mmol) of 2-benzenesulphonyl-3-dimethylamino-acrylonitrile in 60 ml of EtOH and stirred at 40° for 5 hrs. The reaction solution was evaporated and the residue was partitioned between H2O and CH2Cl2. The aqueous phase was washed three times with CH2Cl2, and the combined organic phases were dried (MgSO4), filtered and evaporated. Chromatography (SiO2, CH2Cl2/MeOH 10:1) yielded 2.5 g (30%) of 4-benzenesulphonyl-1H-pyrazol-3-ylamine as a beige powder, m.p. 159-161°.

후처리

  1. customThe reaction solution was evaporated
  2. customthe residue was partitioned between H2O and CH2Cl2
  3. washThe aqueous phase was washed three times with CH2Cl2
  4. dry with materialthe combined organic phases were dried (MgSO4)
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-3b4f7ae3e20142189dc167d1f135ee98
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194410B1

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