methyl 4-[(Z)-2-(4-pyridyl)vinyl]benzoate → Methyl 4-[2-(4-pyridyl)ethyl]benzoate
반응식
[N:1]1[CH:6]=[CH:5][C:4](/[CH:7]=[CH:8]\[C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1>CO.[Pd]>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1참가 물질
4
실험 절차
To a solution of methyl 4-[(Z)-2-(4-pyridyl)vinyl]benzoate (570 mg) in methanol (5.7 ml) was added 10% palladium on carbon, and the mixture was stirred for 4 hours at ambient temperature under hydrogen atmosphere. Insoluble material was filtered off, and the filtrate was concentrated in vacuo. The residue was crystallized with n-hexane to give methyl 4-[2-(4-pyridyl)ethyl]benzoate (539 mg).
후처리
- filtrationInsoluble material was filtered off
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was crystallized with n-hexane
출처 및 근거
- ORD 기록
- ord-70ade6e382b746f3bc0f8ec337b75590
- 출처 데이터셋
- uspto-grants-2001_02
- 특허 번호
- US06194396B1
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