2,3-Dichlorobenzaldehyde → Propan-2-yl 4-(2,3-dichlorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

HRID 636536노트

반응식

HRID 636536 반응식
[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH:11]1([CH:18]=[CH:17][CH:16]=[C:14]([OH:15])[CH2:13]1)O.[NH2:19]/[C:20](/[CH3:28])=[CH:21]\[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]>C(O)(C)C>[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]1[C:13]2[C:14](=[O:15])[CH2:16][CH2:17][CH2:18][C:11]=2[NH:19][C:20]([CH3:28])=[C:21]1[C:22]([O:24][CH:25]([CH3:27])[CH3:26])=[O:23]

참가 물질

5

반응물 3

HCID 357452,3-DichlorobenzaldehydeHCID 111372742-Butenoic acid, 3-amino-, 1-methylethyl esterHCID 19922823Cyclohexa-3,5-diene-1,3-diol

생성물 1

HCID 2847040Propan-2-yl 4-(2,3-dichlorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

3.50 g (20 mmol) of 2,3-dichlorobenzaldehyde, 2.24 g (20 mmol) of dihydroresorcinol and 2.86 g (20 mmol) of isopropyl 3-aminocrotonate are dissolved in 100 ml of isopropanol and stirred under reflux for 5 h. The product precipitates. The mixture is treated with 50 ml of water and cooled to RT. The product is filtered off with suction and washed successively with isopropanol, ethanol and ether. 5.8 g (74% of theory) of the title compound are obtained.

후처리

  1. temperatureunder reflux for 5 h
  2. customThe product precipitates
  3. additionThe mixture is treated with 50 ml of water
  4. filtrationThe product is filtered off with suction
  5. washwashed successively with isopropanol, ethanol and ether

출처 및 근거

ORD 기록
ord-a0fa06fea45c46718f7d1b60eac63f03
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194428B1

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