Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoronicotinic acid → N-(2-fluoronicotinoyl)thiazole-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoronicotinic acid | HCID 96089 | — |
| 반응물 | 4-Thiazolecarboxylic acid | HCID 304271 | — |
| 생성물 | N-(2-fluoronicotinoyl)thiazole-4-carboxylic acid | HCID 21255180 | 41.3% |
반응 단계
N-(2-Fluoronicotinoyl)thiazole-4-carboxylic acid is prepared as described in Example 5 from 11.03 g of thiazole-4-carboxylic acid and 11.7 g of 2-fluoronicotinic acid. 8.7 g of N-(2-fluoronicotinoyl)thiazole-4-carboxylic acid are thus obtained in the form of a cream solid. (Rf=0.33; thin layer chromatography on silica gel; eluent: ethyl acetate/acetic acid, 90/10 by volume).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06194426B1 |
| 출처 데이터셋 | uspto-grants-2001_02 |
| ORD ID | ord-f02f7051a7cb493fb766c2df78543567 |
| 출처 메모 | uspto-grants-2001_02 |