Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 4-[(tert-Butyldimethylsilyl)oxy]-N-methylaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | n-Methyl-p-aminophenol | HCID 5931 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-[(tert-Butyldimethylsilyl)oxy]-N-methylaniline | HCID 13417352 | 43.6% |
반응 단계
A solution of 4-(methylamino)phenol (5.0 g, 29 mmol), TBDMSCl (4.8 g, 32 mmol) and imidazole (9.9 g, 0.15 mol) in DCM was stirred at r.t. for 1 h. Water was added, and the mixture was extracted with EtOAc. The organic layer was dried (Na2SO4), concentrated and purified by silica gel chromatography (PE:EtOAc=10:1) to give 3.0 g (43%) of the title compound as a dark green oil. [M+H] Calc'd for C13H23NOSi, 238. Found, 238.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447046B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-5dd49465ed79419d95b3eac04ff6c8cb |
| 출처 메모 | uspto-grants-2016_09 |