Potassium Hydroxide → Ethyl Acetate

HRID 636649

반응식

HRID 636649 반응식
[C:1]([O:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([O:12][CH3:13])=[CH:7][N:6]=1)(=[O:3])[CH3:2].[OH-].[K+]>CO>[OH:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([O:12][CH3:13])=[CH:7][N:6]=1.[C:1]([O:4][CH2:5][CH3:10])(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 212552792-Acetoxy-methyl-5-methoxy-pyridine

생성물 2

HCID 8857Ethyl Acetate수율 197.9%HCID 178493791HCID 178493791, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of 2-acetoxy-methyl-5-methoxy-pyridine (1.41 g, 7.8 mmol) in methanol (30 mL) was added excess potassium hydroxide (1.6 g), and the mixture was refluxed for 2 hours. The solvent was removed in vacuo, and the residue was purified by column chromatography eluting with a heptane to ethyl acetate gradient. The extremely volatile 2-hydroxy-methyl-5-methoxy-pyridine was obtained as a solution in ethyl acetate (0.68 g, 63% yield).

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by column chromatography
  4. washeluting with a heptane to ethyl acetate gradient

출처 및 근거

ORD 기록
ord-6086957bf3ce42eebbefa4455152d51b
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194437B1

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