Ammonium Chloride → 1,3-Thiazole-2-carboximidamide hydrochloride

HRID 63670노트

반응식

HRID 63670 반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].[Cl-:11].[NH4+:12]>CO>[ClH:11].[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([NH2:12])=[NH:7]

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 10942334Sodium MethoxideHCID 151114801,3-Thiazole-2-carbonitrile

생성물 1

HCID 186795841,3-Thiazole-2-carboximidamide hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a stirred solution of thiazole-2-carbonitrile (1.5 g, 14 mmol) in 5 mL of dry MeOH was added dropwise a solution of sodium methoxide (0.74 g, 14 mmol) in 10 mL of dry methanol. The reaction mixture was stirred at room temperature until the disappearance of starting material which was checked by LC/MS. After that, ammonium chloride (1.5 g, 28 mmol) was added in one portion and the reaction mixture was stirred overnight. The undissolved material was removed by filtration and the filtrate was concentrated to afford thiazole-2-carboxamidine hydrochloride (Compound A1) as a grey solid which was used directly in the next step without further purification. MS: calc'd 128 (MH+), measured 128 (MH+).

후처리

  1. stirringthe reaction mixture was stirred overnight
  2. customThe undissolved material was removed by filtration
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-24aef6e0a5a042c68a0a6ee416267029
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447086B2

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