Water → (2-Fluoro-4-methoxyphenyl)methanol

HRID 636749노트

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HRID 636749 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[F:7][C:8]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:9]=1[C:10](OC)=[O:11].O>C1COCC1>[F:7][C:8]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:9]=1[CH2:10][OH:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 21255685Methyl 2-fluoro-4-methoxybenzoate

생성물 1

HCID 593638(2-Fluoro-4-methoxyphenyl)methanol수율 104%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

To a suspension of LiAlH4 (71.6 mg, 1.89 mmol) in THF (3 ml) was added dropwise a solution of methyl 2-fluoro-4-methoxybenzoate (273.3 mg, 1.48 mmol) in THF (3 ml). The mixture was stirred for 0.5 hours. To the mixture was added dropwise aqueous THF followed by water. The mixture was extracted three times with ethyl acetate and dried over MgSO4. The solvent was evaporated to give the crude title compound (240.4 mg; >99%).

후처리

  1. extractionThe mixture was extracted three times with ethyl acetate
  2. dry with materialdried over MgSO4
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-4436b359decf49398fa62d0241d72553
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194461B1

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