Bromopinacolone → 4-tert-Butyl-thiazole-2-carboxamidine

반응식

[CH:1]1([C:4]2[N:5]=[C:6]([C:9]([NH2:11])=[NH:10])[S:7][CH:8]=2)[CH2:3][CH2:2]1.Br[CH2:13]C(=O)C(C)(C)C>>[C:1]([C:4]1[N:5]=[C:6]([C:9]([NH2:11])=[NH:10])[S:7][CH:8]=1)([CH3:2])([CH3:3])[CH3:13]

참가 물질

반응물 2

HCID 21642Bromopinacolone

HCID 900009164-Cyclopropyl-thiazole-2-carboxamidine

생성물 1

HCID 833857234-tert-Butyl-thiazole-2-carboxamidine

실험 절차

4-tert-Butyl-thiazole-2-carboxamidine (Compound N) was prepared in analogy to Compound M with procedure shown in Example 10 by using 1-bromo-3,3-dimethyl-butan-2-one instead of 2-bromo-1-cyclopropyl-ethanone. MS: calc'd (MH+) 184, measured (MH+) 184.

출처 및 근거

ORD 기록: ord-7fe6473a628d4548aa1af40b68f3751d
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09447086B2

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