Trifluoroacetic acid → HCID 70225437, 화합물

HRID 636803노트

반응식

HRID 636803 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[C:19](=[O:20])[C:18]([CH2:28][C:29]3[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=3)([CH2:21][C:22]3[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=3)[NH:17][C:16]2=[CH:35][C:36]([C:38]2[CH:43]=[CH:42][C:41]([C:44]#[N:45])=[CH:40][CH:39]=2)=[O:37])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:20]=[C:19]1[N:15]([CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:16](=[CH:35][C:36]([C:38]2[CH:39]=[CH:40][C:41]([C:44]#[N:45])=[CH:42][CH:43]=2)=[O:37])[NH:17][C:18]1([CH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1)[CH2:28][C:29]1[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 70224331HCID 70224331, 화합물

생성물 1

HCID 70225437HCID 70225437, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Using the same procedure as described in Example 3, the title compound of 40A (0.958 g, 1.58 mmol) was treated with TFA (3 ml) in CH2Cl2 to give the title compound of 40B (0.621 g, 1.23 mmol, 78% yield).

출처 및 근거

ORD 기록
ord-19ff37683aa04675a75a97d377df68c0
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194438B1

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