Potassium Carbonate → HCID 70222778, 화합물

HRID 636806노트

반응식

HRID 636806 반응식
[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:5](=[CH:14][C:15]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][CH:18]=2)=[O:16])[NH:4][C:3]1([CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1)[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1.[C:39]1([N:45]2[C:49](Cl)=[N:48][N:47]=[N:46]2)[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1.C([O-])([O-])=O.[K+].[K+]>CC#N>[O:1]=[C:2]1[N:6]([CH2:7][CH:8]2[CH2:13][CH2:12][N:11]([C:49]3[N:45]([C:39]4[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=4)[N:46]=[N:47][N:48]=3)[CH2:10][CH2:9]2)[C:5](=[CH:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]([C:21]#[N:22])=[CH:23][CH:24]=2)=[O:16])[NH:4][C:3]1([CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1)[CH2:32][C:33]1[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 842621H-Tetrazole, 5-chloro-1-phenyl-HCID 70225437HCID 70225437, 화합물

생성물 1

HCID 70222778HCID 70222778, 화합물수율 4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of the title compound of 40B (100 mg, 0.20 mmol) and (1-phenyl-1H-tetrazol-5-yl chloride (50 mg, 0.30 mmol) in CH3CN (1 ml) was added K2CO3 (0.08 9, 0.06 mmol). The mixture was stirred overnight. After removal of CH3CN, the reaction mixture was partitioned between CH2Cl2 and H2O. After separation, the organic layer was washed with brine, dried over Na2SO4 and concentrated. The crude product was chromatographed on silica gel with MeOH—CHCl3—NH4OH (1:99:0.1) as eluents to afford the title compound as a white solid, 5 mg (0.077 mmol, 4% yield).

출처 및 근거

ORD 기록
ord-4d9f38872b3d47079f8324142057997a
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194438B1

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