Trifluoroacetic acid → 3-Methylmorpholine-3-carboxylic acid

HRID 63685노트

반응식

HRID 63685 반응식
[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][NH:3]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 223091424-((Tert-butoxy)carbonyl)-3-methylmorpholine-3-carboxylic acid

생성물 1

HCID 836796483-Methylmorpholine-3-carboxylic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3-methyl-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-3-carboxylic acid (Accela ChemBio Co., Ltd., CAS: 1052680-53-1, 50 mg, 0.2.0 mmol) in DCM (1 ml) was added trifluoroacetic acid (1 mL) dropwise at room temperature. The resulting mixture was stirred at room temperature for one hour and then concentrated under the vacuum. The residue was used directly in next step without further purification,

후처리

  1. concentrationconcentrated under the vacuum
  2. customThe residue was used directly in next step without further purification

출처 및 근거

ORD 기록
ord-908386cd59a441989ed9d68678a1eedf
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447086B2

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